^ Shane AL, Cabana MD, Vidry S, Merenstein D, Hummelen R, Ellis CL, Heimbach JT, Hempel S, Lynch SV, Sanders ME, et al. (2010). ": Guide to designing, conducting, publishing and communicating results of clinical studies involving probiotic applications in human participants". Gut Microbes. 1 (4): 243–253. doi:10.4161/gmic.1.4.12707. PMC 3023606. PMID 21327031.
"Short-chain fatty acids are a key component of good gut health," lead study author Hariom Yadav, an assistant professor of molecular medicine at Wake Forest School of Medicine, said in a statement. "People with diabetes, obesity, autoimmune disorders and cancers frequently have fewer short-chain fatty acids. Increasing them may be helpful in maintaining or even restoring a normal gut environment, and hopefully, improving health," Yadav said.
“Aside from the beneficial probiotics, this has plant-based compounds like ginger to soothe upset stomachs and support healthy digestive function,” says Beth Warren, MS, RDN, a dietitian in New York City. It also has prebiotics, which encourage the growth of healthy bacteria that support the well being of pregnant and breastfeeding women, she explains. “The formula has L. rhamnosus HN001, which has been shown to support the child’s developing immune system during the last trimester and early breastfeeding period.”
Inflammatory bowel disease (IBD) treatment with antibiotics is fraught by variable efficacy. Recent discovery of genetic polymorphisms (NOD2/CARD15) in CD which play a role in bacterial peptidoglycan recognition [Inohara et al. 2003; Kobayashi et al. 2005], may be responsive to alterations in enteric flora and thus be important in the pathogenesis and maintenance of IBD [Sartor, 2004].
L. casei also made headlines when a study found it beneficial in relieving anxiety. The randomized, double-blind, placebo-controlled pilot study found supplementation with 24 billion units of the L. casei strain Shirota led to a rise in probiotics lactobacillus and bifidobacterium, as well as a significant decrease in symptoms of anxiety and depression .
Two dangerous diseases in newborns, necrotizing enterocolitis (NEC) and neonatal sepsis, may meet their match with well-designed probiotic supplements. Both of these conditions are common in premature babies and are most dangerous in low birth weight and very low birth weight infants. Research has confirmed that when a pregnant mother takes high-quality probiotics during pregnancy, her baby is significantly less likely to develop either NEC or sepsis, particularly when the baby is breastfed after birth (and mom is still taking the supplements) and/or when probiotics are added to formula. A probiotic supplement with multiple strains seems to be the most effective in these cases.
“Microbiome” refers to the trillions of bacteria and microorganisms that live on and in our individual bodies. “There’s increased recognition of the various ways that the microbiome affects our health,” Lebwohl tells me. “And with that recognition comes the true observation that many bacteria are good for us. This goes against the old idea that bacteria equal germs, which equal harm. It turns out that many bacteria keep us healthy and probiotics could potentially support that notion.”
The probiotic industry is booming, but the benefits of probiotic products and the quantity of viable bacteria they contain can vary. So, instead of adding bacteria from an outside source, you might be better off consuming prebiotics, like fermentable fiber, which support your own beneficial bacteria, Dr. Cresci says. Good dietary sources of prebiotics include dried beans and other legumes, garlic, asparagus, onions, leeks, certain artichokes, green bananas and wheat. Prebiotic supplements are available, as well.
The authors discuss the need for “pscyhobiotics” (probiotics that impact brain function) in handling the development of these conditions. This anti-inflammatory quality is what seems to interest researchers most. While no studies have been conducted in humans, early research suggests that, in animals, probiotic supplements may help alleviate symptoms of anxiety by reducing inflammation along this gut-brain connection.
The other thing to remember is that these microorganisms are not all created equally. In fact, the genus, strain, and species all need to be the same for the results that found in the study to be the results that one hopes to achieve when taking it. For example, with the strain Lactobacillus rhamnosus GG, the genus is Lactobacillus, the species is rhamnosus, and the strain is GG. If any one of those is different in your supplement, you may not attain the same results.
Other ingredients: Maltodextrin, hypromellose (capsule), ferment media (organic Saccharomyces cerevisiae, organic gum acacia, organic soy flour, organic molasses, lactic acid bacteria [Lactobacillus acidophilus, Bifidobacterium bifidum and Lactobacillus rhamnosus], bromelain [deactivated] and papain [deactivated]), glycerin, silicon dioxide, microcrystalline cellulose, rice extract and sunflower oil.
Probiotics are live microorganisms (bacteria or yeast) that have been shown to have a health benefit for humans. They are available in supplement form or in probiotic foods and drinks. Probiotics are thought to be akin to (and to increase the level of) the "good" bacteria found in your intestines. These "good" bacteria are thought to enhance our health through their support of our immune systems.
Very few studies have actually documented survival of an administered probiotic as it transits the gut, by means of fecal recovery studies. One probiotic may not necessarily be translatable to other probiotic(s): for example, different Bifidobacterium species have different tolerances to acid and growth requirements and will have different fecal recovery rates [Matto et al. 2004; Takahashi et al. 2004].
Topping the probiotic market numbers at 100 Billion CFU divided between 34 probiotic strains, Garden of Life’s Ultimate Care probiotic was definitely a contender for our Best Probiotic of 2018. Free from preservatives and additives, RAW scored impressive marks across the board. Although this shortens the lifespan of the probiotics strains somewhat, buying in small quantities can easily solve this problem and – honestly – at CHR we always prefer purity to additives.