In 1907, Russian zoologist Élie Metchinkoff theorized that the gut microbiome could be modified by replacing the harmful bacteria in the digestive tract with beneficial strains instead. He also suggested that the aging process stemmed from the production of toxic substances by specific strains of bacteria in the gut. He believed that fermented foods like sour milk could help lower the pH of the intestinal tract and block the growth of bacteria.


^ Newlove-Delgado TV, Martin AE, Abbott RA, Bethel A, Thompson-Coon J, Whear R, et al. (2017). "Dietary interventions for recurrent abdominal pain in childhood". Cochrane Database Syst Rev. 3: CD010972. doi:10.1002/14651858.CD010972.pub2. PMID 28334433. Overall, there is some evidence to suggest that probiotics may be effective in the treatment of RAP, in terms of improving pain in the shorter term. Clinicians may therefore consider probiotic interventions as part of themanagement strategy for children with RAP (Recurrent Abdominal Pain). However, we were unable to recommend the optimum strain and dosage of probiotic based on this review. The evidence for the effectiveness of probiotics was based largely on shorter-term outcomes. Further trials are required to assess whether improvements in pain are maintained over the longer term; these trials should also consider the importance of using validated and consistent scales to measure pain and other outcomes.

SCFA molecules are a subset of fatty acids that are churned out by some types of gut microbes during the fermentation of fiber. They're associated with maintaining gut health and protecting against disease, so a probiotic containing baby-poop microbes could provide health benefits by boosting SCFA production in a compromised digestive system, researchers reported in the new study. [5 Ways Gut Bacteria Affect Your Health]
The other way that probiotics help is the impact that they have on our immune system. Some believe that this role is the most important. Our immune system is our protection against germs. When it doesn't function properly, we can suffer from allergic reactions, autoimmune disorders (for example, ulcerative colitis, Crohn's disease, and rheumatoid arthritis), and infections (for example, infectious diarrhea, H. pylori, skin infections, and vaginal infections). By maintaining the correct balance from birth, the hope would be to prevent these ailments. Our immune system can benefit anytime that balanced is restored, so it's never too late.

Probiotics also play an important role in maintaining vaginal health. They do so by helping maintain a slightly acidic environment within the vagina, and this helps to reduce the overgrowth of bacteria that might otherwise prove harmful. This is particularly important as there are a variety common events that can negatively affect the vaginal environment including the use of antibiotics, oral contraceptives, and even spermicides.
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As one of the best probiotics for weight loss, there have been a slew of studies demonstrating just how powerful this strain of bacteria may be when it comes to your waistline. For instance, one study in the British Journal of Nutrition showed that taking Lactobacillus gasseri daily led to significant reductions in body weight and body fat compared to a control group, with participants losing up to 8.5 percent body fat over a 12-week period. (13)


The original modern hypothesis of the positive role played by certain bacteria was first introduced by Russian scientist and Nobel laureate Élie Metchnikoff, who in 1907 suggested that it would be possible to modify the gut microbiota and to replace harmful microbes with useful microbes.[9] Metchnikoff, at that time a professor at the Pasteur Institute in Paris, proposed the hypothesis that the aging process results from the activity of putrefactive (proteolytic) microbes producing toxic substances in the large bowel. Proteolytic bacteria such as clostridia, which are part of the normal gut microbiota, produce toxic substances including phenols, indols, and ammonia from the digestion of proteins. According to Metchnikoff, these compounds were responsible for what he called intestinal autointoxication, which would cause the physical changes associated with old age.[54]

"Contrary to the current dogma that probiotics are harmless and benefit everyone, these results reveal a new potential adverse side effect of probiotic use with antibiotics that might even bring long-term consequences," Elinav says. "In contrast, replenishing the gut with one's own microbes is a personalized mother-nature-designed treatment that led to a full reversal of the antibiotics' effects."
Update: I think this product is being smeared by a competitor! Look at all the reviews in April. Suddenly, a butt ton of not just negative but 1 star reviews. It's uncanny. So, what would compel a competitor to do such a thing? Well, it was the only 50 CFU, enteric coated & 20 strain probiotic on Amazon & it cost about 15 bucks. That, while products far inferior to it were priced for - often times - 2 or 3x as much.
Caution: As with any dietary or herbal supplement, you should advise your healthcare professional of the use of this product if you have any medical condition or are taking any medication. If you are nursing, pregnant, or considering pregnancy, consult your healthcare professional prior to using this product. Discontinue use and contact a healthcare professional if you experience an allergic reaction or side effect. Read label ingredients carefully before use and avoid use if known sensitivity to any of the ingredients. Do not exceed suggested use. Keep out of reach of children.
The above line of probiotics is also a favorite of Engelman. "I like Nerium International's new Prolistic Pre & Probiotic Plus Vitamins ($45) because it combines prebiotics, probiotics, and vitamins," Engelman explains. "It supports overall health while targeting digestive function. It contains two types of prebiotics and two strains of probiotics to help enhance levels of beneficial microflora and balance levels of healthy bacteria in the digestive system. Additionally, it contains B vitamins, vitamin C, and vitamin D, which work to enhance the body's immune system and support natural energy production."
From modern diets filled with sugar and additives to exposure to antibiotics in both medicine and food, your lifestyle can wreak havoc on your body’s delicate balance of bacteria. Even aging, stress, environmental toxins, and medications (such as antacids, birth control, and steroids) can have indiscriminate effects on your healthy microflora balance.

Walk into any grocery store, and you will likely find more than a few “probiotic” products brimming with so-called beneficial bacteria that are supposed to treat everything from constipation to obesity to depression. In addition to foods traditionally prepared with live bacterial cultures (such as yogurt and other fermented dairy products), consumers can now purchase probiotic capsules and pills, fruit juices, cereals, sausages, cookies, candy, granola bars and pet food. Indeed, the popularity of probiotics has grown so much in recent years that manufacturers have even added the microorganisms to cosmetics and mattresses.
While the logic behind probiotics might seem sound, it is clear that we have a long way to go before understanding the complexity of the microbiota and the effects—both good and bad—that probiotics might have. All individuals have a unique gut microbiome, and the effects of different bacteria on different people are likely to be highly variable; as such, probiotic use might even need to be personalised for optimal benefits. Commercially available products might not contain the correct strains or quantities of bacteria to provide benefits, and most probiotic supplements contain only single strains, vastly oversimplifying the complexity of the microbiota. While taking a supplement for improved health is certainly an attractive prospect, those looking to aid their gut microbiota might be better served by consuming a healthy, varied diet. In the meantime, rigorous clinical trials are needed to substantiate potential health benefits and to confirm whether probiotics are elixirs or just empty promises. 
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